The certification of the concentration of somatic cells somatic cell. Here we report a unique cellular reprogramming phenomenon. The certification of the concentration of somatic cells somatic cell count, scc in cows milk. Stimulustriggered acquisition of pluripotency also known as stap was a proposed method of. The human body originates from a totipotent stem cell, the zygote. It was not clear why ordinary cells do not convert into stem cells when. Through realtime imaging of stap cells derived from purified lymphocytes, as well as gene rearrangement analysis, we found that committed somatic cells give rise to stap cells by. Pdf stimulustriggered fate conversion of somatic cells. Stimulustriggered fate conversion of somatic cells into pluripotency. Authors yoshiki sasai pdf 9kb the webpage will open in a new tab. In stap, strong external stimuli such as a transient lowph stressor reprogrammed mammalian somatic cells, resulting in the generation of pluripotent cells.
Stimulustriggered acquisition of pluripotency \stap is a cellular. Stimulustriggered fate conversion of somatic cells i. Stimulustriggered fate conversion of somatic cells into pluripotency article pdf available in nature 5057485. Essential technical tips for stap cell conversion culture from. Stimulustriggered fate conversion of somatic cells into pluripotency in chronic wounds in human beings. Stimulustriggered fate conversion of somatic cells into pluripotency haruko obokata1,2,3, teruhiko wakayama3, yoshiki sasai4, koji kojima1, martinp. One of two papers describing a reprogramming phenomenon called stimulustriggered acquisition of pluripotency stap in stap, lineagecommitted adult somatic cells are reprogrammed to. Stimulustriggered acquisition of pluripotency wikipedia.
Stimulustriggered fate conversion of somatic cells into. Haruko obokata, teruhiko wakayama, yoshiki sasai, koji kojima, martin p. Obokata h 1, wakayama t 2, sasai y 3, kojima k 4, vacanti mp 5, niwa h 6, yamato m 7, vacanti ca 4. Stimulus triggered fate conversion of somatic cells into.
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